Matt, if you want to have something Pythonic that is as comprehensive as Rails is, look at TurboGears. Look at version 2.0 that is currently is in beta. The documentation is incomplete, but it is rather usable already. It is built around Pylons providing a neat pre-configured package of everything you need to develop a good website. And if you don’t like parts of it, you can replace parts of it with other things or even write your own parts.
Other people prefer Django, but it is too monolithic, non-modular and heavy to me.

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Come on, TurboGears doesn’t really compare to Rails, it’s more like J2EE ported to Python. The project that was inspired by Rails is really Django – apart from the fact they did better than rails
I’m a Pylons fan but I suggested to Matt a Zine weblog engine
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